Cucurbitacin I

Name Value
Weight 514.659 g/mol
Zinc ID ZINC4097803
Smiles CC(C)(O)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C
Molecular formula C30H42O7
Mode of inhibition JAK2, STAT3; Natural product
CAS 2222-07-3

Clinical Trials

Study title Status Conditions Link
Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media Completed Otitis Media With Effusion NCT02858388

References

Publication DOI Pubmed PMCID
Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition. Neuroscience letters Sun Young Park, Young Hun Kim, Geuntae Park, 609, None, 2015-11-16, 2015-10-22, 10.1016/j.neulet.2015.10.022 10.1016/j.neulet.2015.10.022 26472707 26472707

Vendors

Company Lnk to product
MERCK (Sigma Aldrich) https://www.sigmaaldrich.com/catalog/product/sigma/c4493?lang=pl&region=PL
Caymanchemical https://www.caymanchem.com/product/14747
eMolecules https://orderbb.emolecules.com/search/#?query=48600941&p=1
MedChemExpress https://www.medchemexpress.com/Cucurbitacin-I.html
Tocris https://www.tocris.com/products/cucurbitacin-i_1571
Mcule https://mcule.com/MCULE-8177568528/

Filter data

Compound Cucurbitacin I
Experiment types ELISA, Luciferase activity, MTT, TUNEL assay, Western Blot
Concentrations 0.50
Cell lines Microglia
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT3, p-STAT1, p-STAT3
Other ARE/HO-1, COX-2, Cleaved Caspase-3, ERK, HO-1, HQO1, JAK1, JNK, Nf-κB, Nrf2, TBP, iNOS, p-ERK, p-IκBα, p-JAK1, p-JNK, p-p38, p-p65, p38, p65, tubulin, α-tubulin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Cucurbitacin I ELISA Influence on pro-inflammatory molecules 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin I Luciferase activity Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens p-STAT1
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens STAT1
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens p-STAT3
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens STAT3
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Luciferase activity Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Luciferase activity Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin I Luciferase activity Influence on protein activity in transfected cells 0.50 µM Microglia Homo sapiens
Cucurbitacin I MTT Influence on cell viability 0.50 µM Microglia Homo sapiens
Cucurbitacin I TUNEL assay Influence on cell viability 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on cell viability 0.50 µM Microglia Homo sapiens
Cucurbitacin I Western Blot Influence on cell viability 0.50 µM Microglia Homo sapiens