Cucurbitacin E

Name Value
Weight 556.696 g/mol
Zinc ID ZINC4097800
Smiles CC(=O)OC(C)(C)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C
Molecular formula C32H44O8
Mode of inhibition JAK2, VGFR, STAT3; Natural product
CAS 18444-66-1

Clinical Trials

Study title Status Conditions Link
Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media Completed Otitis Media With Effusion NCT02858388

References

Publication DOI Pubmed PMCID
Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway. Carcinogenesis Yanmin Dong, Binbin Lu, Xiaoli Zhang, Jing Zhang, Li Lai, Dali Li, Yuanyuan Wu, Yajuan Song, Jian Luo, Xiufeng Pang, Zhengfang Yi, Mingyao Liu, 31, 12, None, 2010-08-23, 10.1093/carcin/bgq167 10.1093/carcin/bgq167 20732905 20732905

Vendors

Company Lnk to product
Molport https://www.molport.com/shop/molecule-link/MolPort-020-005-954
AK Scientific Inc. https://aksci.com/item_detail.php?cat=Y0059
Mcule https://mcule.com/MCULE-3358949662/
MedChemExpress https://www.medchemexpress.com/Cucurbitacin-E.html
BLDpharm https://www.bldpharm.com/products/18444-66-1.html
APExBIO https://www.apexbt.com/cucurbitacin-e.html
Biopurify Phytochemicals https://www.phytopurify.com/CucurbitacinE-p-4891.html#gsc.tab=0

Filter data

Compound Cucurbitacin E
Experiment types Body weight, Boyden chamber assay, Chromatin immunoprecipitation assay, ELISA, Flow cytometry , Immunohistochemistry, Luciferase activity, MTT, TUNEL assay, Tubulogenesis , Tumor volume, Tumor weight, Western Blot, Wound healing assay
Concentrations 0.01, 0.10, 0.50, 1.00, 10.00, 3.00
Cell lines HUVEC, Microglia, PC3, PC3(xenograft)
Organisms Homo sapiens, Mus musculus
Animal models c57BL/6
STAT proteins STAT1, STAT3, STAT3(cytoplasmic), STAT3(nuclear), p-STAT1, p-STAT3
Other ARE/HO-1, Bcl-2, Bcl-xL, COX-2, Cleaved Caspase 3, Cleaved Caspase-3, Cyclin D1, CyclinD1, ERK, HO-1, HQO1, JAK1, JAK2, JNK, Nf-κB, Nrf2, PARP, Survivin, TBP, VEGF, VEGFR2, iNOS, p-ERK, p-IκBα, p-JAK1, p-JAK2, p-JNK, p-VEGFR2, p-p38, p-p65, p38, p65, tubulin, α-tubulin, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Cucurbitacin E ELISA Influence on pro-inflammatory molecules 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin E Luciferase activity Influence on proteins levels 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens p-STAT1
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens STAT1
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens p-STAT3
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens STAT3
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Luciferase activity Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Luciferase activity Influence on protein activity 0.50 µM Microglia Homo sapiens
Cucurbitacin E Luciferase activity Influence on protein activity in transfected cells 0.50 µM Microglia Homo sapiens
Cucurbitacin E MTT Influence on cell viability 0.50 µM Microglia Homo sapiens
Cucurbitacin E TUNEL assay Influence on cell viability 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on cell viability 0.50 µM Microglia Homo sapiens
Cucurbitacin E Western Blot Influence on cell viability 0.50 µM Microglia Homo sapiens
Cucurbitacin E Wound healing assay Influence on cell migration 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Wound healing assay Influence on cell migration 0.50 nM HUVEC Homo sapiens
Cucurbitacin E Wound healing assay Influence on cell migration 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Wound healing assay Influence on cell migration 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Boyden chamber assay Influence on cell migration 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Boyden chamber assay Influence on cell migration 0.50 nM HUVEC Homo sapiens
Cucurbitacin E Boyden chamber assay Influence on cell migration 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Boyden chamber assay Influence on cell migration 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Tubulogenesis Influence on cell migration 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Tubulogenesis Influence on cell migration 0.50 nM HUVEC Homo sapiens
Cucurbitacin E Tubulogenesis Influence on cell migration 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Tubulogenesis Influence on cell migration 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Flow cytometry Influence on cell apoptosis 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Flow cytometry Influence on cell apoptosis 0.50 nM HUVEC Homo sapiens
Cucurbitacin E Flow cytometry Influence on cell apoptosis 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Flow cytometry Influence on cell apoptosis 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Flow cytometry Influence on cell apoptosis 0.10 nM PC3 Homo sapiens
Cucurbitacin E Flow cytometry Influence on cell apoptosis 0.50 nM PC3
Cucurbitacin E Flow cytometry Influence on cell apoptosis 1.00 nM PC3 Homo sapiens
Cucurbitacin E Flow cytometry Influence on cell apoptosis 10.00 nM PC3 Homo sapiens
Cucurbitacin E Tumor weight Influence on tumor growth 3.00 mg/kg PC3(xenograft) Mus musculus c57BL/6
Cucurbitacin E Tumor volume Influence on tumor growth 3.00 mg/kg PC3(xenograft) Mus musculus c57BL/6
Cucurbitacin E Body weight Influence on tumor growth 3.00 mg/kg PC3(xenograft) Mus musculus c57BL/6
Cucurbitacin E Immunohistochemistry Influence on tumor angiogenesis 3.00 mg/kg PC3(xenograft) Mus musculus c57BL/6
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM PC3 Homo sapiens p-STAT3
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM PC3 Homo sapiens p-STAT3
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM PC3 Homo sapiens p-STAT3
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM PC3 Homo sapiens p-STAT3
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM PC3 Homo sapiens STAT3
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM PC3 Homo sapiens STAT3
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM PC3 Homo sapiens STAT3
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM PC3 Homo sapiens STAT3
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM PC3 Homo sapiens STAT3(nuclear)
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM PC3 Homo sapiens STAT3(nuclear)
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM PC3 Homo sapiens STAT3(nuclear)
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM PC3 Homo sapiens STAT3(nuclear)
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM PC3 Homo sapiens STAT3(cytoplasmic)
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM PC3 Homo sapiens STAT3(cytoplasmic)
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM PC3 Homo sapiens STAT3(cytoplasmic)
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM PC3 Homo sapiens STAT3(cytoplasmic)
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 0.01 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 0.10 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 1.00 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 10.00 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 0.01 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 0.10 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 1.00 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 10.00 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 0.01 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 0.10 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 1.00 nM PC3 Homo sapiens
Cucurbitacin E Chromatin immunoprecipitation assay Influence on protein activity 10.00 nM PC3 Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.01 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 0.10 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 1.00 nM HUVEC Homo sapiens
Cucurbitacin E Western Blot Influence on protein activity 10.00 nM HUVEC Homo sapiens