CLT-005

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT SH2
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Heterogeneous system degeneration. Subcortical argyrophilic dystrophy. Acta neurologica F Seitelberger, 24, 2, None, None, 10.1167/iovs.16-20641 10.1167/iovs.16-20641 5386345 PMC5386345

Filter data

Compound CLT-005
Experiment types Animal weight, Evans blue-albumin leakage, Glucose levels, Optokinetic Tracking- spatial frequency threshold, Plasma concentration , Rat Cytokine group I 23-Plex Assay, Western Blot, qRT-PCR
Concentrations 1.00, 125.00, 250.00, 5.00, 50.00, 500.00
Cell lines plasma, retina
Organisms Rattus norvegicus
Animal models BN
STAT proteins p-STAT3
Other Actin, GRO/KC, ICAM-1, IL-1β, IL-2, IL-6, LRP-5, LRP-6, MCP-1, TGFβ1, TNF-α, VEGF

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
CLT-005 Evans blue-albumin leakage Influence on angiogenesis 1.00 μg retina Rattus norvegicus BN
CLT-005 Evans blue-albumin leakage Influence on angiogenesis 5.00 μg retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 50.00 ng retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 5.00 μg retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 50.00 ng retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 5.00 μg retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 50.00 ng retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 5.00 μg retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 50.00 ng retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 5.00 μg retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 50.00 ng retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 5.00 μg retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 50.00 ng retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 5.00 μg retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 50.00 ng retina Rattus norvegicus BN
CLT-005 qRT-PCR Influence on angiogenesis 5.00 μg retina Rattus norvegicus BN
CLT-005 Animal weight Organism tollerance 125.00 mg/kg Rattus norvegicus BN
CLT-005 Animal weight Organism tollerance 250.00 mg/kg Rattus norvegicus BN
CLT-005 Animal weight Organism tollerance 500.00 mg/kg Rattus norvegicus BN
CLT-005 Plasma concentration Organism tollerance 125.00 mg/kg plasma Rattus norvegicus BN
CLT-005 Plasma concentration Organism tollerance 250.00 mg/kg plasma Rattus norvegicus BN
CLT-005 Plasma concentration Organism tollerance 500.00 mg/kg plasma Rattus norvegicus BN
CLT-005 Glucose levels Influence on glucose 125.00 mg/kg plasma Rattus norvegicus BN
CLT-005 Glucose levels Influence on glucose 250.00 mg/kg plasma Rattus norvegicus BN
CLT-005 Glucose levels Influence on glucose 500.00 mg/kg plasma Rattus norvegicus BN
CLT-005 Western Blot Influence on protein activity in diabetes 125.00 mg/kg retina Rattus norvegicus BN p-STAT3
CLT-005 Western Blot Influence on protein activity in diabetes 250.00 mg/kg retina Rattus norvegicus BN p-STAT3
CLT-005 Western Blot Influence on protein activity in diabetes 500.00 mg/kg retina Rattus norvegicus BN p-STAT3
CLT-005 Western Blot Influence on protein activity in diabetes 125.00 mg/kg retina Rattus norvegicus BN
CLT-005 Western Blot Influence on protein activity in diabetes 250.00 mg/kg retina Rattus norvegicus BN
CLT-005 Western Blot Influence on protein activity in diabetes 500.00 mg/kg retina Rattus norvegicus BN
CLT-005 Optokinetic Tracking- spatial frequency threshold Influence on vision loss 125.00 mg/kg retina Rattus norvegicus BN
CLT-005 Optokinetic Tracking- spatial frequency threshold Influence on vision loss 250.00 mg/kg retina Rattus norvegicus BN
CLT-005 Optokinetic Tracking- spatial frequency threshold Influence on vision loss 500.00 mg/kg retina Rattus norvegicus BN
CLT-005 Optokinetic Tracking- spatial frequency threshold Influence on cataract severity 125.00 mg/kg retina Rattus norvegicus BN
CLT-005 Optokinetic Tracking- spatial frequency threshold Influence on cataract severity 250.00 mg/kg retina Rattus norvegicus BN
CLT-005 Optokinetic Tracking- spatial frequency threshold Influence on cataract severity 500.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 125.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 250.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 500.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 125.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 250.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 500.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 125.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 250.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 500.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 125.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 250.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 500.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 125.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 250.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 500.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 125.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 250.00 mg/kg retina Rattus norvegicus BN
CLT-005 Rat Cytokine group I 23-Plex Assay Influence on mediators of inflammation 500.00 mg/kg retina Rattus norvegicus BN