C188

Name Value
Weight 433.463 g/mol
Zinc ID ZINC1926256
Smiles O=C(O)CSc1cc(NS(=O)(=O)c2ccc(C(=O)O)cc2)c2ccccc2c1O
Molecular formula C19H15NO7S2
Mode of inhibition Direct STAT
CAS N/A

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
[Studies on the value of breast feeding of children with diseases during the first year of life]. Pediatria polska H Tereszkiewicz, M Bokiniec, 63, 3, None, None, 10.1371/journal.pone.0030207 10.1371/journal.pone.0030207 3412855 22879872
Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget Uddalak Bharadwaj, T Kris Eckols, Xuejun Xu, Moses M Kasembeli, Yunyun Chen, Makoto Adachi, Yongcheng Song, Qianxing Mo, Stephen Y Lai, David J Tweardy, 7, 18, 2016-05-03, None, 10.18632/oncotarget.8368. 10.18632/oncotarget.8368. 27027445 PMC5041982

Filter data

Compound C188
Experiment types FACS, Immunohistochemistry, Kaplan Meier recurence , Luminex, MSFE, MTT, Mammosphere forming efficiency (MSFE), Mean fluorescence, Phosphoflow, SPR, Structure Activity Realtionship SAR, Tumor volume, Western Blot
Concentrations 0.10, 0.30, 1.00, 10.00, 100.00, 12.50, 3.00, 30.00, 300.00, 50.00, N/A
Cell lines 2665A (ER/PgR/HER2-negative and p-Stat3-positive), BCM2665(xengraft), BT549, HN30, Kasumi-1, MC1, SCC-35, SCC-61, SUM159, UM-SCC-17B, UM-SCC-17B(xengraft)
Organisms Homo sapiens, Mus musculus
Animal models SCID Beige mice, nude
STAT proteins STAT1, STAT3, p-STAT1 (Tyr-701), p-STAT3, p-STAT3 (Tyr-705)
Other β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
C188 Mammosphere forming efficiency (MSFE) Influence on tumor growth 10.00 µM SUM159 Homo sapiens
C188 Mammosphere forming efficiency (MSFE) Influence on tumor growth 10.00 µM BT549 Homo sapiens
C188 Tumor volume Influence on tumor growth 12.50 mg/kg BCM2665(xengraft) Mus musculus SCID Beige mice
C188 MSFE Influence on tumor growth 12.50 mg/kg BCM2665(xengraft) Mus musculus SCID Beige mice
C188 Western Blot Influence on tumor growth 12.50 mg/kg BCM2665(xengraft) Mus musculus SCID Beige mice p-STAT3
C188 Western Blot Influence on tumor growth 12.50 mg/kg BCM2665(xengraft) Mus musculus SCID Beige mice
C188 Immunohistochemistry Influence on tumor growth 12.50 mg/kg BCM2665(xengraft) Mus musculus SCID Beige mice p-STAT3
C188 Tumor volume TIC marker measurement 12.50 mg/kg MC1 Mus musculus SCID Beige mice
C188 FACS TIC marker measurement 12.50 mg/kg MC1 Mus musculus SCID Beige mice
C188 Kaplan Meier recurence Influence on tumor growth 12.50 mg/kg 2665A (ER/PgR/HER2-negative and p-Stat3-positive) Mus musculus SCID Beige mice
C188 Structure Activity Realtionship SAR Structure comparision N/A N/A
C188 SPR Biacore sensorchip-immobilized phosphododecapeptide ligand N/A µM Homo sapiens STAT3
C188 Phosphoflow Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Phosphoflow Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Phosphoflow Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Phosphoflow Influence on proteins activity 30.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Phosphoflow Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Phosphoflow Influence on proteins activity 300.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Phosphoflow Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Phosphoflow Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Phosphoflow Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Phosphoflow Influence on proteins activity 30.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Phosphoflow Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Phosphoflow Influence on proteins activity 300.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Mean fluorescence Influence on proteins activity N/A N/A Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Mean fluorescence Influence on proteins activity N/A N/A Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 0.10 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 0.30 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 0.10 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 0.30 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 0.10 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 0.30 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 1.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 3.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 10.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 100.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188 Luminex Influence on proteins activity 0.10 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 0.30 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 1.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 3.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 10.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188 Luminex Influence on proteins activity 100.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188 MTT Influence on cell viability and proliferation 0.10 µM UM-SCC-17B Homo sapiens
C188 MTT Influence on cell viability and proliferation 0.30 µM UM-SCC-17B Homo sapiens
C188 MTT Influence on cell viability and proliferation 1.00 µM UM-SCC-17B Homo sapiens
C188 MTT Influence on cell viability and proliferation 3.00 µM UM-SCC-17B Homo sapiens
C188 MTT Influence on cell viability and proliferation 10.00 µM UM-SCC-17B Homo sapiens
C188 MTT Influence on cell viability and proliferation 100.00 µM UM-SCC-17B Homo sapiens
C188 MTT Influence on cell viability and proliferation 0.10 µM SCC-35 Homo sapiens
C188 MTT Influence on cell viability and proliferation 0.30 µM SCC-35 Homo sapiens
C188 MTT Influence on cell viability and proliferation 1.00 µM SCC-35 Homo sapiens
C188 MTT Influence on cell viability and proliferation 3.00 µM SCC-35 Homo sapiens
C188 MTT Influence on cell viability and proliferation 10.00 µM SCC-35 Homo sapiens
C188 MTT Influence on cell viability and proliferation 100.00 µM SCC-35 Homo sapiens
C188 MTT Influence on cell viability and proliferation 0.10 µM SCC-61 Homo sapiens
C188 MTT Influence on cell viability and proliferation 0.30 µM SCC-61 Homo sapiens
C188 MTT Influence on cell viability and proliferation 1.00 µM SCC-61 Homo sapiens
C188 MTT Influence on cell viability and proliferation 3.00 µM SCC-61 Homo sapiens
C188 MTT Influence on cell viability and proliferation 10.00 µM SCC-61 Homo sapiens
C188 MTT Influence on cell viability and proliferation 100.00 µM SCC-61 Homo sapiens
C188 MTT Influence on cell viability and proliferation 0.10 µM HN30 Homo sapiens
C188 MTT Influence on cell viability and proliferation 0.30 µM HN30 Homo sapiens
C188 MTT Influence on cell viability and proliferation 1.00 µM HN30 Homo sapiens
C188 MTT Influence on cell viability and proliferation 3.00 µM HN30 Homo sapiens
C188 MTT Influence on cell viability and proliferation 10.00 µM HN30 Homo sapiens
C188 MTT Influence on cell viability and proliferation 100.00 µM HN30 Homo sapiens
C188 Tumor volume Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude
C188 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude p-STAT3 (Tyr-705)
C188 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude STAT3
C188 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude
C188 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude p-STAT1 (Tyr-701)
C188 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude STAT1