C188-9

Name Value
Weight 471.534 g/mol
Zinc ID ZINC1154831
Smiles COC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)O)C4=C(C=CC5=CC=CC=C54)O
Molecular formula C27H21NO5S
Mode of inhibition Direct STAT
CAS 432001-19-9

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget Uddalak Bharadwaj, T Kris Eckols, Xuejun Xu, Moses M Kasembeli, Yunyun Chen, Makoto Adachi, Yongcheng Song, Qianxing Mo, Stephen Y Lai, David J Tweardy, 7, 18, 2016-05-03, None, 10.18632/oncotarget.8368. 10.18632/oncotarget.8368. 27027445 PMC5041982
C188-9, a small-molecule STAT3 inhibitor, exerts an antitumor effect on head and neck squamous cell carcinoma. Anti-cancer drugs Jian-Xin Di, Hong-Yan Zhang, 30, 8, None, None, 10.1097/CAD.0000000000000783 10.1097/CAD.0000000000000783 30870229 30870229
STAT3 Contributes To Oncolytic Newcastle Disease Virus-Induced Immunogenic Cell Death in Melanoma Cells 10.3389/fonc.2019.00436 https://www.ncbi.nlm.nih.gov/pubmed/31192135 N/A
STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model. Allergy A C Gavino, K Nahmod, U Bharadwaj, G Makedonas, D J Tweardy, 71, 12, None, 2016-06-23, 10.1111/all.12937 10.1111/all.12937 27225906 27225906
Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands) Katherine M Lewis, Uddalak Bharadwaj, T Kris Eckols, Mikhail Kolosov, Moses M Kasembeli, Colleen Fridley, Ricardo Siller, David J Tweardy, 90, 2, None, 2015-09-15, 10.1016/j.lungcan.2015.09.014 10.1016/j.lungcan.2015.09.014 26410177 PMC4619129

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/c188-9.html
MERCK (Sigma Aldrich) https://www.sigmaaldrich.com/catalog/product/mm/573128?lang=pl&region=PL
BioVision https://www.biovision.com/stat3-inhibitor-c188-142.html
MedChemExpress https://www.medchemexpress.com/C188-9.html
TargetMol https://www.targetmol.com/compound/C188-9
Frontier Scientific Services https://orders.frontierssi.com/fssionline32/public/product.aspx?cat=100081376&type=hts
AK Scientific Inc. https://aksci.com/item_detail.php?cat=Y0002
AK Scientific Inc. https://aksci.com/item_detail.php?cat=J10967
1PlusChem https://www.1pchem.com/prod/88191-48-4
1PlusChem https://www.1pchem.com/prod/7295-85-4
Matrix Scientific http://www.matrixscientific.com/098363.html
AmBeed https://www.ambeed.com/products/13392-26-2.html
PiChemicals http://www.pipharm.com/catalog_products/PI-41475.html
Specs https://www.specs.net/index.php?page=search_show_structure&structureId=AE-765/20006021&guest=Y&message=GUEST%20user%20view...
TargetMol https://www.targetmol.com/compound/%28+%29-Catechin-Hydrate
TargetMol https://www.targetmol.com/compound/Catechin
Ambinter http://www.ambinter.com/reference/Amb22169908
Ambinter http://www.ambinter.com/reference/Amb22467753
Ambinter http://www.ambinter.com/reference/Amb2747278
Ambinter http://www.ambinter.com/reference/Amb540975
Ambinter http://www.ambinter.com/reference/Amb6350547
Mcule https://mcule.com/MCULE-4219942050/
MolCore https://www.molcore.com/product/490-46-0
BLDpharm https://www.bldpharm.com/products/13392-26-2.html
BLDpharm https://www.bldpharm.com/products/35323-91-2.html

Filter data

Compound C188-9
Experiment types Alcian Blue-PAS staining, Cell cycle analysis, Colony formation assay , ELISA, Flow cytometry , Immunofluorescence, Luciferase activity, Luminex, Luminex beads, MTT, Mean fluorescence, Phosphoflow, RT-PCR, SPR, Structure Activity Realtionship SAR, Tumor volume, Tumor volume, weight, Virus yield examination, Western Blot, Wound healing assay
Concentrations 0.00, 0.01, 0.03, 0.10, 0.30, 0.90, 1.00, 10.00, 100.00, 3.00, 30.00, 300.00, 50.00, N/A
Cell lines A375, A549, A549(xenograft), C8161, CAL27, H1299, H1437, H1563, H1573, H1975, H2126, H661, HBEC, HBEC3-KT, HN30, Hep-2, Kasumi-1, MEF-STAT3α, MEF-STAT3β, SCC-35, SCC-61, SCC15, SCC25, SCC9, UM-SCC-17B, UM-SCC-17B(xengraft), bronchoalveolar lavage fluid, lung tissue, serum
Organisms Homo sapiens, Mus musculus
Animal models c57BL/6, nude
STAT proteins STAT1, STAT3, STAT3α, STAT3β, p-STAT1 (Tyr-701), p-STAT3, p-STAT3 (Tyr-705)
Other Bcl-2, Bcl-xL, Cyclin D1, GAPDH, H3, HMGB1, HMGB1 (concentrate), HMGB1 (lysate), HN, HSP70 (concentrate), HSP70 (lysate), HSP90 (concentrate), HSP90 (lysate), IL-13, IL-17, IL-4, IL-5, PARP, Survivin , cleaved Caspase3, cleaved-PARP, p-eIF2α, p62, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
C188-9 Structure Activity Realtionship SAR Structure comparision N/A N/A
C188-9 SPR Biacore sensorchip-immobilized phosphododecapeptide ligand N/A µM Homo sapiens STAT3
C188-9 Phosphoflow Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 30.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 300.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Phosphoflow Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Phosphoflow Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Phosphoflow Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Phosphoflow Influence on proteins activity 30.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Phosphoflow Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Phosphoflow Influence on proteins activity 300.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Mean fluorescence Influence on proteins activity N/A N/A Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Mean fluorescence Influence on proteins activity N/A N/A Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 0.10 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 0.30 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 0.10 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 0.30 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 1.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 3.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 10.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 100.00 µM Kasumi-1 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 0.10 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 0.30 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 1.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 3.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 10.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 100.00 µM UM-SCC-17B Homo sapiens p-STAT3 (Tyr-705)
C188-9 Luminex Influence on proteins activity 0.10 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 0.30 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 1.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 3.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 10.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 Luminex Influence on proteins activity 100.00 µM UM-SCC-17B Homo sapiens p-STAT1 (Tyr-701)
C188-9 MTT Influence on cell viability and proliferation 0.10 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.30 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 1.00 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 3.00 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 10.00 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 100.00 µM UM-SCC-17B Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.10 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.30 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 1.00 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 3.00 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 10.00 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 100.00 µM SCC-35 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.10 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.30 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 1.00 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 3.00 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 10.00 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 100.00 µM SCC-61 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.10 µM HN30 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 0.30 µM HN30 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 1.00 µM HN30 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 3.00 µM HN30 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 10.00 µM HN30 Homo sapiens
C188-9 MTT Influence on cell viability and proliferation 100.00 µM HN30 Homo sapiens
C188-9 Tumor volume Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude
C188-9 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude p-STAT3 (Tyr-705)
C188-9 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude STAT3
C188-9 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude
C188-9 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude p-STAT1 (Tyr-701)
C188-9 Western Blot Influence on tumor growth 50.00 mg/kg UM-SCC-17B(xengraft) Mus musculus nude STAT1
C188-9 Western Blot Level of STAT3 estimation N/A N/A Hep-2 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Level of STAT3 estimation N/A N/A Hep-2 Homo sapiens STAT3
C188-9 Western Blot Level of STAT3 estimation N/A N/A Hep-2 Homo sapiens
C188-9 Western Blot Level of STAT3 estimation N/A N/A CAL27 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Level of STAT3 estimation N/A N/A CAL27 Homo sapiens STAT3
C188-9 Western Blot Level of STAT3 estimation N/A N/A CAL27 Homo sapiens
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC9 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC9 Homo sapiens STAT3
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC9 Homo sapiens
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC15 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC15 Homo sapiens STAT3
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC25 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC25 Homo sapiens STAT3
C188-9 Western Blot Level of STAT3 estimation N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on proteins level N/A N/A SCC15 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Western Blot Influence on proteins level N/A N/A SCC15 Homo sapiens STAT1
C188-9 Western Blot Influence on proteins level N/A N/A SCC15 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Influence on proteins level N/A N/A SCC15 Homo sapiens STAT3
C188-9 Western Blot Influence on proteins level N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on proteins level N/A N/A SCC25 Homo sapiens p-STAT1 (Tyr-701)
C188-9 Western Blot Influence on proteins level N/A N/A SCC25 Homo sapiens STAT1
C188-9 Western Blot Influence on proteins level N/A N/A SCC25 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Influence on proteins level N/A N/A SCC25 Homo sapiens STAT3
C188-9 Western Blot Influence on proteins level N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on nuclear translocation N/A N/A SCC15 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Influence on nuclear translocation N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on nuclear translocation N/A N/A SCC25 Homo sapiens p-STAT3 (Tyr-705)
C188-9 Western Blot Influence on nuclear translocation N/A N/A SCC25 Homo sapiens
C188-9 Luciferase activity Influence on transcriptional activity N/A N/A SCC15 Homo sapiens STAT3
C188-9 Luciferase activity Influence on transcriptional activity N/A N/A SCC25 Homo sapiens STAT3
C188-9 Colony formation assay Influence on cell proliferation N/A N/A SCC15 Homo sapiens
C188-9 Colony formation assay Influence on cell proliferation N/A N/A SCC25 Homo sapiens
C188-9 MTT Influence on cell proliferation N/A N/A SCC15 Homo sapiens
C188-9 MTT Influence on cell proliferation N/A N/A SCC25 Homo sapiens
C188-9 Cell cycle analysis Influence on cell proliferation N/A N/A SCC15 Homo sapiens
C188-9 Cell cycle analysis Influence on cell proliferation N/A N/A SCC25 Homo sapiens
C188-9 Flow cytometry Influence on cell apoptosis N/A N/A SCC15 Homo sapiens
C188-9 Flow cytometry Influence on cell apoptosis N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cell apoptosis N/A N/A SCC25 Homo sapiens
C188-9 Wound healing assay Influence on cell mobility N/A N/A SCC15 Homo sapiens
C188-9 Wound healing assay Influence on cell mobility N/A N/A SCC25 Homo sapiens
C188-9 MTT Influence on cisplatin cell sensitivity N/A N/A SCC15 Homo sapiens
C188-9 MTT Influence on cisplatin cell sensitivity N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC15 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on cisplatin cell sensitivity N/A N/A SCC25 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein 0.90 µM C8161 Homo sapiens
C188-9 Immunofluorescence Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Immunofluorescence Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Flow cytometry Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Flow cytometry Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 Western Blot Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 ELISA Influence on protein in presence of IL6 0.90 µM A375 Homo sapiens
C188-9 ELISA Influence on protein in presence of IL6 0.90 µM C8161 Homo sapiens
C188-9 Virus yield examination Influence on protein in presence of IL6 and vrus 0.90 µM A375 Homo sapiens
C188-9 Virus yield examination Influence on protein in presence of IL6 and vrus 0.90 µM C8161 Homo sapiens
C188-9 Luminex Influence on STAT3 levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6 p-STAT3
C188-9 Luminex Influence on STAT3 levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6 STAT3
C188-9 Alcian Blue-PAS staining Influence on lung epithelium thickness in presence of house dust mite 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex Influence on cytokine levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex Influence on cytokine levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex Influence on cytokine levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex Influence on cytokine levels in lung tissue in presence of house dust mites 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex Influence on cytokine levels in serum in presence of house dust mites 10.00 mg/kg serum Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg bronchoalveolar lavage fluid Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg bronchoalveolar lavage fluid Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg bronchoalveolar lavage fluid Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg bronchoalveolar lavage fluid Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD4+ T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD3- T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD3- T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD3- T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Flow cytometry Effect of inhibitor on cytokine frequencies expressing CD3- T cells 10.00 mg/kg lung tissue Mus musculus c57BL/6
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A HBEC Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H1563 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H1437 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H661 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H2126 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A A549 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H1573 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H1299 Homo sapiens
C188-9 Luminex STAT3 activation level in NSCLC cell lines N/A N/A H1975 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3α Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3β Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC3-KT Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1563 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1437 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H661 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H2126 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A A549 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1573 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1299 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1975 Homo sapiens STAT3α
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3α Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3β Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC3-KT Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1563 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1437 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H661 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H2126 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A A549 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1573 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1299 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1975 Homo sapiens STAT3β
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3α Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A MEF-STAT3β Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC3-KT Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A HBEC Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1563 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1437 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H661 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H2126 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A A549 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1573 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1299 Homo sapiens
C188-9 Western Blot STAT3 activation level in various cell lines N/A N/A H1975 Homo sapiens
C188-9 Luminex beads Influence o protein levels 30.00 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 0.00 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 0.03 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 0.01 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 0.30 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 0.10 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 1.00 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 3.00 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 10.00 µM A549 Homo sapiens p-STAT3
C188-9 Luminex beads Influence o protein levels 100.00 µM A549 Homo sapiens p-STAT3
C188-9 MTT Influence on cell proliferation 0.00 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 0.03 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 0.01 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 0.30 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 0.10 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 1.00 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 3.00 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 10.00 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 30.00 µM A549 Homo sapiens
C188-9 MTT Influence on cell proliferation 100.00 µM A549 Homo sapiens
C188-9 RT-PCR Influence on STAT3 target gene expression 30.00 µM A549 Homo sapiens
C188-9 RT-PCR Influence on STAT3 target gene expression 30.00 µM A549 Homo sapiens
C188-9 RT-PCR Influence on STAT3 target gene expression 30.00 µM A549 Homo sapiens
C188-9 RT-PCR Influence on STAT3 target gene expression 30.00 µM A549 Homo sapiens
C188-9 Flow cytometry Influence on apoptosis 30.00 µM A549 Homo sapiens
C188-9 Tumor volume, weight Influence on tumor growth 50.00 mg/kg A549(xenograft) Mus musculus
C188-9 RT-PCR Influence on STAT3 target gene expression in tumor 50.00 mg/kg A549(xenograft) Mus musculus
C188-9 RT-PCR Influence on STAT3 target gene expression in tumor 50.00 mg/kg A549(xenograft) Mus musculus
C188-9 RT-PCR Influence on STAT3 target gene expression in tumor 50.00 mg/kg A549(xenograft) Mus musculus
C188-9 RT-PCR Influence on STAT3 target gene expression in tumor 50.00 mg/kg A549(xenograft) Mus musculus