Brevilin A

Name Value
Weight 346.423 g/mol
Zinc ID ZINC5132563
Smiles C/C=C(/C)\C(=O)O[C@H]1[C@@H]2[C@@H](C(=O)O[C@@H]2C[C@H]([C@H]3[C@]1(C(=O)C=C3)C)C)C
Molecular formula C20H26O5
Mode of inhibition Direct JAK inhibitor; indirect STAT3; Natural product
CAS 16503-32-5

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Brevilin A Induces Cell Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma. Frontiers in pharmacology Rui Liu, Zhao Qu, Yushan Lin, Chi-Sing Lee, William Chi-Shing Tai, Sibao Chen, 10, None, None, 2019-05-24, 10.3389/fphar.2019.00594 10.3389/fphar.2019.00594 31178739 PMC6544084
Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. PloS one Xing Chen, Yuping Du, Jing Nan, Xinxin Zhang, Xiaodong Qin, Yuxin Wang, Jianwen Hou, Qin Wang, Jinbo Yang, 8, 5, None, 2013-05-21, 10.1371/journal.pone.0063697 10.1371/journal.pone.0063697 23704931 PMC3660600
The JAK2/STAT3 pathway is involved in the anti-melanoma effects of atractylenolide I. Experimental dermatology Xiu-Qiong Fu, Ji-Yao Chou, Ting Li, Pei-Li Zhu, Jun-Kui Li, Cheng-Le Yin, Tao Su, Hui Guo, Kin-Wah Lee, Muhammad Jahangir Hossen, Gui-Xin Chou, Zhi-Ling Yu, 27, 2, None, 2018-01-05, 10.1016/j.lfs.2019.117169 10.1016/j.lfs.2019.117169 29078004 29078004

Vendors

Company Lnk to product
MedChemExpress https://www.medchemexpress.com/brevilin-a.html

Filter data

Compound Brevilin A
Experiment types Annexin-V-PI dual staining, Average mouse body weight , Average tumor volume, Average tumor weight , Confocal microscopy- DAPI, Flow cytometry , Invasiveness, Luciferase Assay , MTT, MTT Assay , RT-PCR, RT-qPCR, Tumor volume and weight, mouse body weight, Western Blot, Wound healing assay
Concentrations 0.25, 0.50, 1.00, 1.25, 1.56, 10.00, 12.00, 12.50, 15.00, 16.00, 17.50, 2.00, 2.50, 20.00, 25.00, 3.00, 3.12, 4.00, 4.50, 40.00, 5.00, 50.00, 6.25, 7.50, 8.00, 80.00, 9.00
Cell lines A2058, A375, A375 (STAT3), A549R, CNE-2, CNE-2 (xenograft), DU145, HEK293T, HEK293T (JAK1-JH1), HEK293T (JAK2-JH1), HEK293T (JAK3-JH1), HEK293T (Tyk2-JH1), HaCaT, Hela, HepG2, MDA-MB-468, hTERT-BJ
Organisms Homo sapiens, Mus musculus
Animal models BALB/c nude
STAT proteins STAT1, STAT3, STAT3 (cytoplasmic), STAT3 (nuclear), p-STAT3, pTyr701-STAT1, pTyr705-STAT3
Other AKT, Anti-His, BCL-XL, Bax, Bcl-2, Cdc2, Cdk6, Cleaved PARP, Cyclin B1, Cyclin D3, CyclinD1, ERK, Full-length PARP, GAPDH, Gapdh, JAK2, JAK2-JH1, MCL-1, MMP-9, PARP, PCNA, PI3K110α, PI3Kp85, Socs3, Src, Tyk2-JH1, anti-pTyr, c-Myc, cleaved PARP, cleaved caspase 9, cleaved-PARP, cleaved-caspase-3, cleaved-caspase-7, cleaved-caspase-8, cleaved-caspase-9, mTOR, p-AKT, p-AKT (Ser473), p-ERK (Thr202/Thr204), p-JAK2 (Tyr1007/1008), p-PI3Kp85, p-mTOR, p65, pSer473-AKT, pSer536-p65, pSer9-GSK-3β, pTyr1054/1055-Tyk2, pro-caspase-3, pro-caspase-7, pro-caspase-8, pro-caspase-9, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Brevilin A MTT Assay Influence on proliferation 50.00 µM CNE-2 Homo sapiens
Brevilin A MTT Assay Influence on proliferation 25.00 µM CNE-2 Homo sapiens
Brevilin A MTT Assay Influence on proliferation 12.50 µM CNE-2 Homo sapiens
Brevilin A MTT Assay Influence on proliferation 6.25 µM CNE-2 Homo sapiens
Brevilin A MTT Assay Influence on proliferation 3.12 µM CNE-2 Homo sapiens
Brevilin A MTT Assay Influence on proliferation 1.56 µM CNE-2 Homo sapiens
Brevilin A Confocal microscopy- DAPI Influence on cell morphology 2.50 µM CNE-2 Homo sapiens
Brevilin A Confocal microscopy- DAPI Influence on cell morphology 5.00 µM CNE-2 Homo sapiens
Brevilin A Confocal microscopy- DAPI Influence on cell morphology 10.00 µM CNE-2 Homo sapiens
Brevilin A Flow cytometry Influence on cell cycle 1.25 µM CNE-2 Homo sapiens
Brevilin A Flow cytometry Influence on cell cycle 2.50 µM CNE-2 Homo sapiens
Brevilin A Flow cytometry Influence on cell cycle 5.00 µM CNE-2 Homo sapiens
Brevilin A Flow cytometry Influence on cell cycle 7.50 µM CNE-2 Homo sapiens
Brevilin A Flow cytometry Influence on cell cycle 10.00 µM CNE-2 Homo sapiens
Brevilin A Flow cytometry Influence on apoptosis 1.25 µM CNE-2 Homo sapiens
Brevilin A Flow cytometry Influence on apoptosis 2.50 µM CNE-2 Homo sapiens
Brevilin A Flow cytometry Influence on apoptosis 5.00 µM CNE-2 Homo sapiens
Brevilin A Flow cytometry Influence on apoptosis 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on cell cycle proteins 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on apoptotic proteins 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 20.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 1.25 µM CNE-2 Homo sapiens p-STAT3
Brevilin A Western Blot Influence on PI3K/AKT pathway members 2.50 µM CNE-2 Homo sapiens p-STAT3
Brevilin A Western Blot Influence on PI3K/AKT pathway members 5.00 µM CNE-2 Homo sapiens p-STAT3
Brevilin A Western Blot Influence on PI3K/AKT pathway members 10.00 µM CNE-2 Homo sapiens p-STAT3
Brevilin A Western Blot Influence on PI3K/AKT pathway members 20.00 µM CNE-2 Homo sapiens p-STAT3
Brevilin A Western Blot Influence on PI3K/AKT pathway members 1.25 µM CNE-2 Homo sapiens STAT3
Brevilin A Western Blot Influence on PI3K/AKT pathway members 2.50 µM CNE-2 Homo sapiens STAT3
Brevilin A Western Blot Influence on PI3K/AKT pathway members 5.00 µM CNE-2 Homo sapiens STAT3
Brevilin A Western Blot Influence on PI3K/AKT pathway members 10.00 µM CNE-2 Homo sapiens STAT3
Brevilin A Western Blot Influence on PI3K/AKT pathway members 20.00 µM CNE-2 Homo sapiens STAT3
Brevilin A Western Blot Influence on PI3K/AKT pathway members 1.25 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 2.50 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 5.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 10.00 µM CNE-2 Homo sapiens
Brevilin A Western Blot Influence on PI3K/AKT pathway members 20.00 µM CNE-2 Homo sapiens
Brevilin A Average tumor volume Influence on tumor growth 10.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Average tumor volume Influence on tumor growth 20.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Average tumor weight Influence on tumor growth 10.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Average tumor weight Influence on tumor growth 20.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Average mouse body weight Influence on tumor growth 10.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Average mouse body weight Influence on tumor growth 20.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Western Blot Influence on PI3K/AKT and STAT3 signaling pathways 10.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Western Blot Influence on PI3K/AKT and STAT3 signaling pathways 20.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Western Blot Influence on PI3K/AKT and STAT3 signaling pathways 10.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Western Blot Influence on PI3K/AKT and STAT3 signaling pathways 20.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Western Blot Influence on PI3K/AKT and STAT3 signaling pathways 10.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude p-STAT3
Brevilin A Western Blot Influence on PI3K/AKT and STAT3 signaling pathways 20.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude p-STAT3
Brevilin A Western Blot Influence on PI3K/AKT and STAT3 signaling pathways 10.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude STAT3
Brevilin A Western Blot Influence on PI3K/AKT and STAT3 signaling pathways 20.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude STAT3
Brevilin A Western Blot Influence on PI3K/AKT and STAT3 signaling pathways 10.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Western Blot Influence on PI3K/AKT and STAT3 signaling pathways 20.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude
Brevilin A Western Blot Influence on STAT3 signalling 12.50 µM A549R Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on STAT3 signalling 25.00 µM A549R Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on STAT3 signalling 12.50 µM A549R Homo sapiens STAT3
Brevilin A Western Blot Influence on STAT3 signalling 25.00 µM A549R Homo sapiens STAT3
Brevilin A Western Blot Influence on STAT3 signalling 12.50 µM A549R Homo sapiens
Brevilin A Western Blot Influence on STAT3 signalling 25.00 µM A549R Homo sapiens
Brevilin A MTT Influence on STAT3 signalling 20.00 µM A549R Homo sapiens
Brevilin A MTT Influence on STAT3 signalling 17.50 µM A549R Homo sapiens
Brevilin A MTT Influence on STAT3 signalling 15.00 µM A549R Homo sapiens
Brevilin A MTT Influence on STAT3 signalling 12.50 µM A549R Homo sapiens
Brevilin A MTT Influence on STAT3 signalling 10.00 µM A549R Homo sapiens
Brevilin A MTT Influence on STAT3 signalling 7.50 µM A549R Homo sapiens
Brevilin A MTT Influence on STAT3 signalling 5.00 µM A549R Homo sapiens
Brevilin A MTT Influence on STAT3 signalling 2.50 µM A549R Homo sapiens
Brevilin A MTT Influence on STAT3 signalling 1.00 µM A549R Homo sapiens
Brevilin A Luciferase Assay Influence on STAT3 signalling 20.00 µM A549R Homo sapiens
Brevilin A Luciferase Assay Influence on STAT3 signalling 17.50 µM A549R Homo sapiens
Brevilin A Luciferase Assay Influence on STAT3 signalling 15.00 µM A549R Homo sapiens
Brevilin A Luciferase Assay Influence on STAT3 signalling 12.50 µM A549R Homo sapiens
Brevilin A Luciferase Assay Influence on STAT3 signalling 10.00 µM A549R Homo sapiens
Brevilin A Luciferase Assay Influence on STAT3 signalling 7.50 µM A549R Homo sapiens
Brevilin A Luciferase Assay Influence on STAT3 signalling 5.00 µM A549R Homo sapiens
Brevilin A Luciferase Assay Influence on STAT3 signalling 2.50 µM A549R Homo sapiens
Brevilin A Luciferase Assay Influence on STAT3 signalling 1.00 µM A549R Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 5.00 µM DU145 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM DU145 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 15.00 µM DU145 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 5.00 µM DU145 Homo sapiens STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM DU145 Homo sapiens STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 15.00 µM DU145 Homo sapiens STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 5.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 15.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 5.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 15.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 5.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 15.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 5.00 µM MDA-MB-468 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM MDA-MB-468 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 15.00 µM MDA-MB-468 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 5.00 µM MDA-MB-468 Homo sapiens STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM MDA-MB-468 Homo sapiens STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 15.00 µM MDA-MB-468 Homo sapiens STAT3
Brevilin A Western Blot Influence on constitutive STAT3 activation 5.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 15.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 5.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 15.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 5.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 15.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM DU145 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on constitutive STAT3 activation 10.00 µM MDA-MB-468 Homo sapiens
Brevilin A MTT Influence on cell growth 5.00 µM hTERT-BJ Homo sapiens
Brevilin A MTT Influence on cell growth 5.00 µM DU145 Homo sapiens
Brevilin A MTT Influence on cell growth 5.00 µM MDA-MB-468 Homo sapiens
Brevilin A MTT Influence on cell growth 10.00 µM hTERT-BJ Homo sapiens
Brevilin A MTT Influence on cell growth 10.00 µM DU145 Homo sapiens
Brevilin A MTT Influence on cell growth 10.00 µM MDA-MB-468 Homo sapiens
Brevilin A Annexin-V-PI dual staining Influence on cell growth 10.00 µM hTERT-BJ Homo sapiens
Brevilin A Annexin-V-PI dual staining Influence on cell growth 10.00 µM DU145 Homo sapiens
Brevilin A Annexin-V-PI dual staining Influence on cell growth 10.00 µM MDA-MB-468 Homo sapiens
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM HEK293T Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM Hela Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM HepG2 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM HEK293T Homo sapiens STAT3
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM Hela Homo sapiens STAT3
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM HepG2 Homo sapiens STAT3
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM Hela Homo sapiens
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM HepG2 Homo sapiens
Brevilin A RT-PCR Influence on protein upon cytokine treatment 10.00 µM HEK293T Homo sapiens
Brevilin A RT-PCR Influence on protein upon cytokine treatment 10.00 µM Hela Homo sapiens
Brevilin A RT-PCR Influence on protein upon cytokine treatment 10.00 µM HepG2 Homo sapiens
Brevilin A RT-PCR Influence on protein upon cytokine treatment 10.00 µM HEK293T Homo sapiens
Brevilin A RT-PCR Influence on protein upon cytokine treatment 10.00 µM Hela Homo sapiens
Brevilin A RT-PCR Influence on protein upon cytokine treatment 10.00 µM HepG2 Homo sapiens
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM Hela Homo sapiens
Brevilin A Western Blot Influence on protein upon cytokine treatment 10.00 µM Hela Homo sapiens pTyr701-STAT1
Brevilin A Western Blot Influence on JAK2-JH1 overexpressed protein 10.00 µM HEK293T Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on JAK2-JH1 overexpressed protein 15.00 µM HEK293T Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on JAK2-JH1 overexpressed protein 10.00 µM HEK293T Homo sapiens STAT3
Brevilin A Western Blot Influence on JAK2-JH1 overexpressed protein 15.00 µM HEK293T Homo sapiens STAT3
Brevilin A Western Blot Influence on JAK2-JH1 overexpressed protein 10.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on JAK2-JH1 overexpressed protein 15.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on JAK2-JH1 overexpressed protein 10.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on JAK2-JH1 overexpressed protein 15.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on c-Src overexpressed protein 15.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on c-Src overexpressed protein 15.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on c-Src overexpressed protein 15.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK1-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK1-JH1) Homo sapiens pTyr701-STAT1
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT1
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK1-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK1-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK1-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK2-JH1) Homo sapiens pTyr701-STAT1
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT1
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK2-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK2-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK2-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK3-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK3-JH1) Homo sapiens STAT3
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK3-JH1) Homo sapiens pTyr701-STAT1
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK3-JH1) Homo sapiens STAT1
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK3-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK3-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (JAK3-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (Tyk2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (Tyk2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (Tyk2-JH1) Homo sapiens pTyr701-STAT1
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (Tyk2-JH1) Homo sapiens STAT1
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (Tyk2-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (Tyk2-JH1) Homo sapiens
Brevilin A Western Blot Influence on protein overexpression 15.00 µM HEK293T (Tyk2-JH1) Homo sapiens
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 10.00 µM HEK293T Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 20.00 µM HEK293T Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 40.00 µM HEK293T Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 80.00 µM HEK293T Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 10.00 µM HEK293T Homo sapiens STAT3
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 20.00 µM HEK293T Homo sapiens STAT3
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 40.00 µM HEK293T Homo sapiens STAT3
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 80.00 µM HEK293T Homo sapiens STAT3
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 10.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 20.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 40.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain 80.00 µM HEK293T Homo sapiens
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 5.00 µM HEK293T (JAK1-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 7.50 µM HEK293T (JAK1-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 10.00 µM HEK293T (JAK1-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 12.50 µM HEK293T (JAK1-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 15.00 µM HEK293T (JAK1-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 17.50 µM HEK293T (JAK1-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 20.00 µM HEK293T (JAK1-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 5.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 7.50 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 10.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 12.50 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 15.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 17.50 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 20.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 5.00 µM HEK293T (JAK2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 7.50 µM HEK293T (JAK2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 10.00 µM HEK293T (JAK2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 12.50 µM HEK293T (JAK2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 15.00 µM HEK293T (JAK2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 17.50 µM HEK293T (JAK2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 20.00 µM HEK293T (JAK2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 5.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 7.50 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 10.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 12.50 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 15.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 17.50 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 20.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 5.00 µM HEK293T (JAK3-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 7.50 µM HEK293T (JAK3-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 10.00 µM HEK293T (JAK3-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 12.50 µM HEK293T (JAK3-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 15.00 µM HEK293T (JAK3-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 17.50 µM HEK293T (JAK3-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 20.00 µM HEK293T (JAK3-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 5.00 µM HEK293T (JAK3-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 7.50 µM HEK293T (JAK3-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 10.00 µM HEK293T (JAK3-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 12.50 µM HEK293T (JAK3-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 15.00 µM HEK293T (JAK3-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 17.50 µM HEK293T (JAK3-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 20.00 µM HEK293T (JAK3-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 5.00 µM HEK293T (Tyk2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 7.50 µM HEK293T (Tyk2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 10.00 µM HEK293T (Tyk2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 12.50 µM HEK293T (Tyk2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 15.00 µM HEK293T (Tyk2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 17.50 µM HEK293T (Tyk2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 20.00 µM HEK293T (Tyk2-JH1) Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 5.00 µM HEK293T (Tyk2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 7.50 µM HEK293T (Tyk2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 10.00 µM HEK293T (Tyk2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 12.50 µM HEK293T (Tyk2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 15.00 µM HEK293T (Tyk2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 17.50 µM HEK293T (Tyk2-JH1) Homo sapiens STAT3
Brevilin A Western Blot Measurement of IC50 value JAKs-JH1 truncated kinases 20.00 µM HEK293T (Tyk2-JH1) Homo sapiens STAT3
Brevilin A Tumor volume and weight, mouse body weight Influence on tumor growth 4.50 mg/kg A375 Mus musculus
Brevilin A Tumor volume and weight, mouse body weight Influence on tumor growth 9.00 mg/kg A375 Mus musculus
Brevilin A Western Blot Influence on protein levels in tumor tissue 4.50 mg/kg A375 Mus musculus pTyr705-STAT3
Brevilin A Western Blot Influence on protein levels in tumor tissue 9.00 mg/kg A375 Mus musculus pTyr705-STAT3
Brevilin A Western Blot Influence on protein levels in tumor tissue 4.50 mg/kg A375 Mus musculus STAT3
Brevilin A Western Blot Influence on protein levels in tumor tissue 9.00 mg/kg A375 Mus musculus STAT3
Brevilin A MTT Influence on cell viability 0.50 µM A375 Homo sapiens
Brevilin A MTT Influence on cell viability 1.00 µM A375 Homo sapiens
Brevilin A MTT Influence on cell viability 2.00 µM A375 Homo sapiens
Brevilin A MTT Influence on cell viability 4.00 µM A375 Homo sapiens
Brevilin A MTT Influence on cell viability 8.00 µM A375 Homo sapiens
Brevilin A MTT Influence on cell viability 12.00 µM A375 Homo sapiens
Brevilin A MTT Influence on cell viability 16.00 µM A375 Homo sapiens
Brevilin A MTT Influence on cell viability 0.50 µM A2058 Homo sapiens
Brevilin A MTT Influence on cell viability 1.00 µM A2058 Homo sapiens
Brevilin A MTT Influence on cell viability 2.00 µM A2058 Homo sapiens
Brevilin A MTT Influence on cell viability 4.00 µM A2058 Homo sapiens
Brevilin A MTT Influence on cell viability 8.00 µM A2058 Homo sapiens
Brevilin A MTT Influence on cell viability 12.00 µM A2058 Homo sapiens
Brevilin A MTT Influence on cell viability 16.00 µM A2058 Homo sapiens
Brevilin A MTT Influence on cell viability 0.50 µM HaCaT Homo sapiens
Brevilin A MTT Influence on cell viability 1.00 µM HaCaT Homo sapiens
Brevilin A MTT Influence on cell viability 2.00 µM HaCaT Homo sapiens
Brevilin A MTT Influence on cell viability 4.00 µM HaCaT Homo sapiens
Brevilin A MTT Influence on cell viability 8.00 µM HaCaT Homo sapiens
Brevilin A MTT Influence on cell viability 12.00 µM HaCaT Homo sapiens
Brevilin A MTT Influence on cell viability 16.00 µM HaCaT Homo sapiens
Brevilin A Annexin-V-PI dual staining Influence on cell viability 1.00 µM A375 Homo sapiens
Brevilin A Annexin-V-PI dual staining Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Annexin-V-PI dual staining Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Annexin-V-PI dual staining Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Annexin-V-PI dual staining Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Annexin-V-PI dual staining Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on apoptosis 3.00 µM A2058 Homo sapiens
Brevilin A Wound healing assay Influence on cell migration 0.25 µM A375 Homo sapiens
Brevilin A Wound healing assay Influence on cell migration 0.50 µM A375 Homo sapiens
Brevilin A Wound healing assay Influence on cell migration 0.25 µM A2058 Homo sapiens
Brevilin A Wound healing assay Influence on cell migration 0.50 µM A2058 Homo sapiens
Brevilin A Invasiveness Influence on cell migration 0.50 µM A375 Homo sapiens
Brevilin A Invasiveness Influence on cell migration 0.50 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A375 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A375 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A375 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A2058 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A2058 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A2058 Homo sapiens pTyr705-STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A375 Homo sapiens STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A375 Homo sapiens STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A375 Homo sapiens STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A2058 Homo sapiens STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A2058 Homo sapiens STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A2058 Homo sapiens STAT3
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on JAK2/STAT3 signalling in melanoma cells 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 1.00 µM A375 Homo sapiens STAT3 (cytoplasmic)
Brevilin A Western Blot Influence on STAT3 nuclear localization 2.00 µM A375 Homo sapiens STAT3 (cytoplasmic)
Brevilin A Western Blot Influence on STAT3 nuclear localization 3.00 µM A375 Homo sapiens STAT3 (cytoplasmic)
Brevilin A Western Blot Influence on STAT3 nuclear localization 1.00 µM A2058 Homo sapiens STAT3 (cytoplasmic)
Brevilin A Western Blot Influence on STAT3 nuclear localization 2.00 µM A2058 Homo sapiens STAT3 (cytoplasmic)
Brevilin A Western Blot Influence on STAT3 nuclear localization 3.00 µM A2058 Homo sapiens STAT3 (cytoplasmic)
Brevilin A Western Blot Influence on STAT3 nuclear localization 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 1.00 µM A375 Homo sapiens STAT3 (nuclear)
Brevilin A Western Blot Influence on STAT3 nuclear localization 2.00 µM A375 Homo sapiens STAT3 (nuclear)
Brevilin A Western Blot Influence on STAT3 nuclear localization 3.00 µM A375 Homo sapiens STAT3 (nuclear)
Brevilin A Western Blot Influence on STAT3 nuclear localization 1.00 µM A2058 Homo sapiens STAT3 (nuclear)
Brevilin A Western Blot Influence on STAT3 nuclear localization 2.00 µM A2058 Homo sapiens STAT3 (nuclear)
Brevilin A Western Blot Influence on STAT3 nuclear localization 3.00 µM A2058 Homo sapiens STAT3 (nuclear)
Brevilin A Western Blot Influence on STAT3 nuclear localization 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on STAT3 nuclear localization 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 3.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 3.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 0.50 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 1.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 2.00 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 0.50 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 1.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 2.00 µM A2058 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 0.50 µM A375 Homo sapiens
Brevilin A Western Blot Influence on protein and mRNA levels on STAT3 target genes 0.50 µM A2058 Homo sapiens
Brevilin A RT-qPCR Influence on protein and mRNA levels on STAT3 target genes 0.50 µM A375 Homo sapiens
Brevilin A RT-qPCR Influence on protein and mRNA levels on STAT3 target genes 1.00 µM A375 Homo sapiens
Brevilin A RT-qPCR Influence on protein and mRNA levels on STAT3 target genes 2.00 µM A375 Homo sapiens
Brevilin A RT-qPCR Influence on protein and mRNA levels on STAT3 target genes 0.50 µM A2058 Homo sapiens
Brevilin A RT-qPCR Influence on protein and mRNA levels on STAT3 target genes 1.00 µM A2058 Homo sapiens
Brevilin A RT-qPCR Influence on protein and mRNA levels on STAT3 target genes 2.00 µM A2058 Homo sapiens
Brevilin A MTT Influence on STAT3 overexpression in cell migration and viability assays 1.00 µM A375 Homo sapiens
Brevilin A MTT Influence on STAT3 overexpression in cell migration and viability assays 2.00 µM A375 Homo sapiens
Brevilin A MTT Influence on STAT3 overexpression in cell migration and viability assays 3.00 µM A375 Homo sapiens
Brevilin A MTT Influence on STAT3 overexpression in cell migration and viability assays 1.00 µM A375 (STAT3) Homo sapiens
Brevilin A MTT Influence on STAT3 overexpression in cell migration and viability assays 2.00 µM A375 (STAT3) Homo sapiens
Brevilin A MTT Influence on STAT3 overexpression in cell migration and viability assays 3.00 µM A375 (STAT3) Homo sapiens