BP-1-108

Name Value
Weight 0.000 g/mol
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition N/A
CAS 1334492-85-1

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity. Journal of medicinal chemistry Brent D G Page, Haytham Khoury, Rob C Laister, Steven Fletcher, Megan Vellozo, Alessia Manzoli, Peibin Yue, James Turkson, Mark D Minden, Patrick T Gunning, 55, 3, 2012-02-09, 2012-01-13, 10.1021/jm200720n 10.1021/jm200720n 22148584 22148584

Vendors

Company Lnk to product
MedKoo Biosciences https://www.medkoo.com/products/29346

Filter data

Compound BP-1-108
Experiment types Chromatin immunoprecipitation assay, Flow cytometry , RT-PCR, Western Blot
Concentrations 10.00, 20.00, 40.00
Cell lines K562
Organisms Homo sapiens
Animal models
STAT proteins STAT5, p-STAT3, p-STAT5
Other Cyclin D1, Cyclin D2, GAPDH, Mcl-1, Mcl1, c-Myc, p-AKT

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
BP-1-108 Western Blot Influence on protein activity 40.00 µM K562 Homo sapiens p-STAT5
BP-1-108 Western Blot Influence on protein activity 40.00 µM K562 Homo sapiens STAT5
BP-1-108 Western Blot Influence on protein activity 40.00 µM K562 Homo sapiens
BP-1-108 Flow cytometry Influence on protein activity 40.00 µM K562 Homo sapiens p-STAT5
BP-1-108 Flow cytometry Influence on protein activity 20.00 µM K562 Homo sapiens p-STAT5
BP-1-108 Flow cytometry Influence on protein activity 10.00 µM K562 Homo sapiens p-STAT5
BP-1-108 Flow cytometry Influence on protein activity 40.00 µM K562 Homo sapiens p-STAT3
BP-1-108 Flow cytometry Influence on protein activity 40.00 µM K562 Homo sapiens
BP-1-108 RT-PCR Influence on trancriptional activity 40.00 µM K562 Homo sapiens
BP-1-108 RT-PCR Influence on trancriptional activity 40.00 µM K562 Homo sapiens
BP-1-108 RT-PCR Influence on trancriptional activity 40.00 µM K562 Homo sapiens
BP-1-108 RT-PCR Influence on trancriptional activity 40.00 µM K562 Homo sapiens
BP-1-108 Chromatin immunoprecipitation assay Influence on protein activity 40.00 µM K562 Homo sapiens
BP-1-108 Chromatin immunoprecipitation assay Influence on protein activity 40.00 µM K562 Homo sapiens
BP-1-108 Western Blot Influence on protein activity 40.00 µM K562 Homo sapiens p-STAT5
BP-1-108 Western Blot Influence on protein activity 40.00 µM K562 Homo sapiens STAT5
BP-1-108 Western Blot Influence on protein activity 40.00 µM K562 Homo sapiens
BP-1-108 RT-PCR Influence on expression of STAT target genes 40.00 µM K562 Homo sapiens
BP-1-108 RT-PCR Influence on expression of STAT target genes 40.00 µM K562 Homo sapiens
BP-1-108 RT-PCR Influence on expression of STAT target genes 40.00 µM K562 Homo sapiens
BP-1-108 RT-PCR Influence on expression of STAT target genes 40.00 µM K562 Homo sapiens