Atractylenolide II

Name Value
Weight 232.323 g/mol
Zinc ID ZINC15207329
Smiles C=C1CCC[C@]2(C)C[C@@H]3OC(=O)C(C)=C3C[C@@H]12
Molecular formula C15H20O2
Mode of inhibition JAK and STAT inhibitor
CAS 73069-14-4

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Atractylenolide II Induces Apoptosis of Prostate Cancer Cells through Regulation of AR and JAK2/STAT3 Signaling Pathways. Molecules (Basel, Switzerland) Jing Wang, Moussa Ide Nasser, Salah Adlat, Ming Ming Jiang, Nan Jiang, Li Gao, 23, 12, 2018-12-12, 2018-12-12, 10.3390/molecules23123298 10.3390/molecules23123298 30545141 PMC6320989

Vendors

Company Lnk to product
ChemFaces http://www.chemfaces.com/natural/Atractylenolide-CFN99945.html
Selleckchem https://www.selleckchem.com/products/atractylenolide-ii.html
MedChemExpress https://www.medchemexpress.com/Atractylenolide-II.html
Adooq https://www.adooq.com/2-atractylenolide.html
Caymanchemicals https://www.caymanchem.com/product/24911
Abmole http://www.abmole.com/products/atractylenolide-ii.html

Filter data

Compound Atractylenolide II
Experiment types Flow cytometry , Flow cytometry- annexin V binding and propidium iodide staining, MTT Assay , Western Blot
Concentrations 100.00, 12.50, 200.00, 25.00, 50.00, 6.00
Cell lines BPH1, DU145, LNCaP
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3
Other Akt, Bax, Bcl-2, CDK1, Caspase-3, Caspase-9, Cleaved Caspase-3, Cleaved Caspase-9, Cleaved-PARP, Cyclin B1, Cytochrome C, JAK-2, MDM2, PARP, p-Akt, p-ERK, p-JAK2, p-Pi3k, p21, p53, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Atractylenolide II MTT Assay Influence on cell proliferation 6.00 µM DU145 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 12.50 µM DU145 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 25.00 µM DU145 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 50.00 µM DU145 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 100.00 µM DU145 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 200.00 µM DU145 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 6.00 µM BPH1 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 12.50 µM BPH1 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 25.00 µM BPH1 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 50.00 µM BPH1 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 100.00 µM BPH1 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 200.00 µM BPH1 Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 6.00 µM LNCaP Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 12.50 µM LNCaP Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 25.00 µM LNCaP Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 50.00 µM LNCaP Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 100.00 µM LNCaP Homo sapiens
Atractylenolide II MTT Assay Influence on cell proliferation 200.00 µM LNCaP Homo sapiens
Atractylenolide II Flow cytometry Influence on cell cycle 50.00 µM LNCaP Homo sapiens
Atractylenolide II Flow cytometry Influence on cell cycle 100.00 µM LNCaP Homo sapiens
Atractylenolide II Flow cytometry Influence on cell cycle 50.00 µM DU145 Homo sapiens
Atractylenolide II Flow cytometry Influence on cell cycle 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on cell cycle protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Flow cytometry- annexin V binding and propidium iodide staining Influence on apoptosis 50.00 µM LNCaP Homo sapiens
Atractylenolide II Flow cytometry- annexin V binding and propidium iodide staining Influence on apoptosis 100.00 µM LNCaP Homo sapiens
Atractylenolide II Flow cytometry- annexin V binding and propidium iodide staining Influence on apoptosis 50.00 µM DU145 Homo sapiens
Atractylenolide II Flow cytometry- annexin V binding and propidium iodide staining Influence on apoptosis 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on apoptosis protein activity in presence of Z-VAD-FMK, TNF-α 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM LNCaP Homo sapiens p-STAT3
Atractylenolide II Western Blot Influence on protein activity 100.00 µM LNCaP Homo sapiens p-STAT3
Atractylenolide II Western Blot Influence on protein activity 50.00 µM DU145 Homo sapiens p-STAT3
Atractylenolide II Western Blot Influence on protein activity 100.00 µM DU145 Homo sapiens p-STAT3
Atractylenolide II Western Blot Influence on protein activity 50.00 µM LNCaP Homo sapiens STAT3
Atractylenolide II Western Blot Influence on protein activity 100.00 µM LNCaP Homo sapiens STAT3
Atractylenolide II Western Blot Influence on protein activity 50.00 µM DU145 Homo sapiens STAT3
Atractylenolide II Western Blot Influence on protein activity 100.00 µM DU145 Homo sapiens STAT3
Atractylenolide II Western Blot Influence on protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM LNCaP Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 50.00 µM DU145 Homo sapiens
Atractylenolide II Western Blot Influence on protein activity 100.00 µM DU145 Homo sapiens