Andrographolide derivative

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Nf-κB, STAT; Natural product
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice. Bioorganic & medicinal chemistry Shao-Ru Chen, Feng Li, Mo-Yu Ding, Decai Wang, Qi Zhao, Yitao Wang, Guo-Chun Zhou, Ying Wang, 26, 18, 2018-10-01, 2018-09-04, 10.1016/j.bmc.2018.09.002 10.1016/j.bmc.2018.09.002 30228000 30228000

Filter data

Compound Andrographolide derivative
Experiment types Body weight, Immunostaining , RT-qPCR, Western Blot
Concentrations 10.00, 30.00
Cell lines AD-293, liver
Organisms Homo sapiens, Mus musculus
Animal models BALB/c
STAT proteins STAT1, STAT3, p-STAT1(Y701), p-STAT3(Y705)
Other Actin, IL-6, Ki67, MCP-1, PCNA, SMAD2, SMAD3 , SMAD4, TGF-β

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Andrographolide derivative Western Blot Influence on protein-protein interaction in presence of IFNγ 10.00 µM AD-293 Homo sapiens p-STAT1(Y701)
Andrographolide derivative Western Blot Influence on protein-protein interaction in presence of IFNγ 10.00 µM AD-293 Homo sapiens STAT1
Andrographolide derivative Western Blot Influence on protein-protein interaction in presence of IFNγ 10.00 µM AD-293 Homo sapiens p-STAT3(Y705)
Andrographolide derivative Western Blot Influence on protein-protein interaction in presence of IFNγ 10.00 µM AD-293 Homo sapiens STAT3
Andrographolide derivative Western Blot Influence on protein-protein interaction in presence of IFNγ 10.00 µM AD-293 Homo sapiens
Andrographolide derivative Body weight Influence on liver damage 30.00 mg/kg liver Mus musculus BALB/c
Andrographolide derivative Immunostaining Influence on liver damage 30.00 mg/kg liver Mus musculus BALB/c
Andrographolide derivative Immunostaining Influence on liver damage 30.00 mg/kg liver Mus musculus BALB/c
Andrographolide derivative RT-qPCR Influence on CCl4-induced inflammation 30.00 mg/kg liver Mus musculus BALB/c STAT3
Andrographolide derivative RT-qPCR Influence on CCl4-induced inflammation 30.00 mg/kg liver Mus musculus BALB/c
Andrographolide derivative RT-qPCR Influence on CCl4-induced inflammation 30.00 mg/kg liver Mus musculus BALB/c
Andrographolide derivative RT-qPCR Influence on CCl4-induced inflammation 30.00 mg/kg liver Mus musculus BALB/c
Andrographolide derivative RT-qPCR Influence on CCl4-induced inflammation 30.00 mg/kg liver Mus musculus BALB/c
Andrographolide derivative RT-qPCR Influence on CCl4-induced inflammation 30.00 mg/kg liver Mus musculus BALB/c
Andrographolide derivative RT-qPCR Influence on CCl4-induced inflammation 30.00 mg/kg liver Mus musculus BALB/c