5,15-DPP

Name Value
Weight 462.556 g/mol
Zinc ID ZINC100012460
Smiles c1ccc(-c2c3ccc(cc4ccc([nH]4)c(-c4ccccc4)c4ccc(cc5ccc2[nH]5)n4)n3)cc1
Molecular formula C32H22N4
Mode of inhibition Direct STAT; Natural product
CAS 22112-89-6

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
Novel high-throughput screening system for identifying STAT3-SH2 antagonists. Biochemical and biophysical research communications Yutaka Uehara, Masato Mochizuki, Kenji Matsuno, Takeharu Haino, Akira Asai, 380, 3, 2009-03-13, 2009-01-27, 10.1016/j.bbrc.2009.01.137 10.1016/j.bbrc.2009.01.137 19285012 19285012
IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nature communications Rei Nakamura, Abdoulaye Sene, Andrea Santeford, Abdelaziz Gdoura, Shunsuke Kubota, Nicole Zapata, Rajendra S Apte, 6, None, 2015-08-11, 2015-08-11, 10.1038/ncomms8847 10.1038/ncomms8847 26260587 PMC4918330

Vendors

Company Lnk to product
MERCK (Sigma Aldrich) https://www.sigmaaldrich.com/catalog/product/sigma/sml1906?lang=pl&region=PL&gclid=Cj0KCQiAs67yBRC7ARIsAF49CdWrcrIdQ3zrKKBxo7Ob69p7FK689Ab0E4Q7rFaFQlQtdFbGhcs9lYMaApy6EALw_wcB
Axon Medchem https://www.axonmedchem.com/product/1992
Selleckchem https://www.selleckchem.com/products/as1517499.html
MedChemExpress https://www.medchemexpress.com/AS1517499.html
TargetMol https://www.targetmol.com/compound/AS1517499
BLDpharm https://www.bldpharm.com/products/919486-40-1.html
Glpbio https://www.glpbio.com/as1517499.html
AbMole https://www.abmole.com/products/as1517499.html

Filter data

Compound 5,15-DPP
Experiment types Chromatin immunoprecipitation , DNA binding activity assay, FRET, Immunohistochemistry, Western Blot, [3H] thymidine
Concentrations 10.00, 20.00, 5.00, 50.00
Cell lines 264.7 RAW, HEK293, HMVEC, MDA-MB-468
Organisms Homo sapiens, Mus musculus
Animal models
STAT proteins STAT1, STAT3, STAT3α, STAT5A, STAT5B, p-STAT3 (Y705), p-STAT3(Y705)
Other c-Myc, α-tubulin, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 10.00 µM MDA-MB-468 Homo sapiens STAT3
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 20.00 µM MDA-MB-468 Homo sapiens STAT3
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 50.00 µM MDA-MB-468 Homo sapiens STAT3
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 10.00 µM MDA-MB-468 Homo sapiens STAT1
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 20.00 µM MDA-MB-468 Homo sapiens STAT1
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 50.00 µM MDA-MB-468 Homo sapiens STAT1
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 10.00 µM MDA-MB-468 Homo sapiens STAT5A
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 20.00 µM MDA-MB-468 Homo sapiens STAT5A
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 50.00 µM MDA-MB-468 Homo sapiens STAT5A
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 10.00 µM MDA-MB-468 Homo sapiens STAT5B
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 20.00 µM MDA-MB-468 Homo sapiens STAT5B
5,15-DPP DNA binding activity assay Influence on protein-DNA interaction in presence of IL-6 50.00 µM MDA-MB-468 Homo sapiens STAT5B
5,15-DPP FRET Influence on protein activity 10.00 µM HEK293 Homo sapiens
5,15-DPP FRET Influence on protein activity 20.00 µM HEK293 Homo sapiens
5,15-DPP FRET Influence on protein activity 50.00 µM HEK293 Homo sapiens
5,15-DPP Chromatin immunoprecipitation Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
5,15-DPP Chromatin immunoprecipitation Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens
5,15-DPP Chromatin immunoprecipitation Influence on protein activity 50.00 µM MDA-MB-468 Homo sapiens
5,15-DPP Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens p-STAT3(Y705)
5,15-DPP Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens p-STAT3(Y705)
5,15-DPP Western Blot Influence on protein activity 50.00 µM MDA-MB-468 Homo sapiens p-STAT3(Y705)
5,15-DPP Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens STAT3
5,15-DPP Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens STAT3
5,15-DPP Western Blot Influence on protein activity 50.00 µM MDA-MB-468 Homo sapiens STAT3
5,15-DPP Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
5,15-DPP Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens
5,15-DPP Western Blot Influence on protein activity 50.00 µM MDA-MB-468 Homo sapiens
5,15-DPP Western Blot Influence on protein activity 10.00 µM MDA-MB-468 Homo sapiens
5,15-DPP Western Blot Influence on protein activity 20.00 µM MDA-MB-468 Homo sapiens
5,15-DPP Western Blot Influence on protein activity 50.00 µM MDA-MB-468 Homo sapiens
5,15-DPP Immunohistochemistry Influence on protin activity in presence of IL-10 5.00 mM 264.7 RAW Mus musculus STAT3
5,15-DPP Western Blot Influence on protin activity in presence of IL-10 5.00 mM 264.7 RAW Mus musculus p-STAT3 (Y705)
5,15-DPP Western Blot Influence on protin activity in presence of IL-10 5.00 mM 264.7 RAW Mus musculus STAT3α
5,15-DPP Western Blot Influence on protin activity in presence of IL-10 5.00 mM 264.7 RAW Mus musculus
5,15-DPP [3H] thymidine Influence on cell proliferation in presence of IL-10 5.00 mM HMVEC Mus musculus